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Updated: Jul 16, 2025

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
Published on: December 22, 2023
[Catecholaminergic polymorphic ventricular tachycardia in adolescents: a clinical, electrocardiographic and genetic
María Concepción Rocha-Arrieta1, Antonio Arias-Díaz2, Carlos Alberto Quiróz-Romero3
1Universidad de Cartagena. Cartagena, Colombia. Universidad de Cartagena Universidad de Cartagena Cartagena Colombia.
Abstract:
Catecholaminergic polymorphic ventricular tachycardia is one of the most lethal channelopathies, characterized by ventricular arrhythmias triggered by stress or physical activity. We present the case of an adolescent who consulted for recurrent syncope precipitated by exercise. In the diagnostic approach, catecholaminergic polymorphic ventricular tachycardia was reached, with a mutation in the cardiac ryanodine receptor gene, Heterozygous c.14311G> A (p.v4771I exon 100), antiarrhythmic drugs and implantable cardioverter-defibrillator were necessary with satisfactory evolution. Clinical suspicion, stress test and genetic tests are essential for a timely diagnosis and management of this pathology.
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