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Gender Differences in Prognosis After Primary Resection for Retroperitoneal Liposarcoma
Li Ren1, Yuhan Qi1,2, Jichun Zhao1
1Division of Vascular Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.
The American Surgeon
|September 20, 2023
Summary
Men may face worse survival outcomes after retroperitoneal liposarcoma (RLPS) resection compared to women. This disparity is particularly pronounced in men with low-grade tumors or those undergoing non-radical surgery.
Area of Science:
- Oncology
- Surgical Oncology
- Epidemiology
Background:
- Limited data exists on gender differences in retroperitoneal liposarcoma (RLPS).
- Investigating gender's impact on prognosis after primary RLPS resection is crucial.
Purpose of the Study:
- To determine if gender influences survival outcomes in patients undergoing primary resection of retroperitoneal liposarcoma.
- To identify specific subgroups where gender disparities in RLPS prognosis are most evident.
Main Methods:
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database for patient identification (1973-2015).
- Employed multivariate Cox proportional hazard analysis to assess survival outcomes.
- Calculated adjusted hazard ratios (AHR) and 95% confidence intervals (CIs).
Main Results:
- Analysis included 2108 RLPS patients (971 women, 1137 men).
- Men showed a higher risk of all-cause mortality (AHR 1.3) but not disease-specific mortality.
- Increased mortality risk in men was observed in low-grade tumors and non-radical resection subgroups.
Conclusions:
- Men may experience poorer survival post-RLPS resection than women.
- Gender-based survival disparities are significant in low-grade RLPS and after non-radical resection.
- Attention to gender-specific factors in RLPS management is warranted.
