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Selection criteria for oral contraceptive use. Current concepts.
The Journal of Reproductive Medicine
|September 1, 1986
Summary
Steroid dosages in oral contraceptives have decreased significantly since the 1960s, leading to reduced health risks. Further research is needed on newer formulations like triphasics to confirm their benefits.
Area of Science:
- Reproductive Health
- Pharmacology
- Women's Health
Background:
- Oral contraceptives (OCs) have evolved significantly since their introduction.
- Early OCs contained high steroid dosages, associated with notable health risks.
- Modern OCs feature substantially reduced steroid content.
Purpose of the Study:
- To review the impact of declining steroid dosages in oral contraceptives.
- To assess the relationship between dosage reduction and major OC-associated risks.
- To identify potential advantages of current OC formulations.
Main Methods:
- Literature review and analysis of historical data on OC formulations.
- Examination of epidemiological studies on OC-related risks.
- Comparative analysis of different OC dosage regimens.
Main Results:
- A substantial decline in steroid dosages of OCs since the 1960s has been observed.
- Evidence suggests a corresponding reduction in major risks associated with OC use.
- The safety profile of OCs has improved with lower-dose formulations.
Conclusions:
- Reduced steroid dosages in oral contraceptives have likely decreased associated health risks.
- Current low-dose formulations represent a significant safety improvement.
- Further investigation into the specific benefits of newer preparations, such as triphasic OCs, is warranted.