Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

237
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
237
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

190
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
190
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

326
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
326
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

305
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
305
Taste Buds and Receptors01:20

Taste Buds and Receptors

2.2K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
2.2K
The Physiology of Taste01:24

The Physiology of Taste

4.0K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Commentary on the controversies, challenges, and missteps of the Minnesota Guidelines process from the perspective of the Steering Committee.

The Clinical neuropsychologist·2026
Same author

Editorial: Introducing the Minnesota Conference Guidelines on Education and Training in Clinical Neuropsychology.

The Clinical neuropsychologist·2026
Same author

Implementing the Minnesota Conference Guidelines in doctoral, internship, fellowship, and continuing education programs.

The Clinical neuropsychologist·2026
Same author

From Houston to Minnesota: The commission to plan the updating of neuropsychology's training guidelines.

The Clinical neuropsychologist·2025
Same author

Proceedings of the Minnesota 2022 conference on clinical neuropsychology training guidelines.

The Clinical neuropsychologist·2025
Same author

The Minnesota Conference proposed guidelines for education and training in clinical neuropsychology.

The Clinical neuropsychologist·2025

Related Experiment Video

Updated: Jul 16, 2025

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
05:56

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

Published on: June 21, 2024

879

Chemotherapy-Induced Taste Alteration.

Suzanne Penna1

  • 1Memorial Sloan Kettering Cancer Center.

Clinical Journal of Oncology Nursing
|September 20, 2023
PubMed
Summary

Chemotherapy commonly causes taste alterations, impacting patient quality of life. Consistent clinical evaluation of these taste changes is needed.

Area of Science:

  • Oncology
  • Clinical Nutrition
  • Patient-Reported Outcomes

Background:

  • Taste alteration is a frequent side effect of chemotherapy.
  • This condition significantly affects patients' quality of life.
  • There is a lack of consistent evaluation of taste alteration in clinical settings.

Purpose of the Study:

  • To highlight the prevalence and impact of chemotherapy-induced taste alterations.
  • To emphasize the need for systematic assessment of taste changes in cancer patients.
  • To review the existing literature supporting the evaluation of taste alteration.

Main Methods:

  • Literature review of studies on chemotherapy side effects.
  • Analysis of patient-reported outcomes related to taste.
Keywords:
CiTASdysgeusiamiracle fruitphotobiomodulationtaste alteration

More Related Videos

Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells
07:57

Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells

Published on: April 5, 2021

4.4K
Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
07:42

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

18.2K

Related Experiment Videos

Last Updated: Jul 16, 2025

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
05:56

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

Published on: June 21, 2024

879
Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells
07:57

Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells

Published on: April 5, 2021

4.4K
Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
07:42

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

18.2K
  • Examination of clinical guidelines and practices for managing taste alterations.

    • Main Results:

    • Chemotherapy frequently leads to dysgeusia (taste alteration).
    • Taste changes negatively impact nutritional intake and quality of life.
    • Current clinical practice often overlooks systematic taste assessment.

    Conclusions:

    • Consistent evaluation of taste alteration is crucial in clinical practice.
    • Addressing taste changes can improve patient adherence and outcomes.
    • Further research is needed to standardize taste assessment protocols.