The Relationship between Allergic Disease and Sexual Dysfunction: A Scoping Review.

Area of Science:

• Reproductive Medicine
• Immunology
• Public Health

Background:

• Sexual dysfunction (SD) and allergic diseases are prevalent global health issues.
• A potential relationship between these conditions necessitates further investigation.
• Existing data on the association between allergic diseases and SD requires comprehensive analysis.

Purpose of the Study:

• To conduct a scoping review analyzing available data on the association between allergic diseases and sexual dysfunction.
• To synthesize findings regarding the impact of allergic conditions on sexual function metrics.

Main Methods:

• A comprehensive literature search was performed across major databases (PubMed, MEDLINE, Embase, CENTRAL, Web of Science) for studies published before January 2023.
• Twelve observational studies were included in the review.
• Narrative synthesis was employed to analyze the effects of allergic diseases on SD, utilizing the Female Sexual Function Index (FSFI) and International Index of Erectile Function (IIEF).

Main Results:

• Included studies generally indicated lower FSFI or IIEF scores in individuals with asthma, allergic rhinitis, allergic rhinoconjunctivitis, and urticaria compared to healthy controls.
• Potential contributing factors identified include inflammation, psychological effects, hormonal shifts, sleep disturbances, and medication use.
• The findings suggest a consistent pattern of impaired sexual function in the presence of various allergic conditions.

Conclusions:

• The extant literature supports an interrelationship between sexual dysfunction and allergic diseases.
• This review highlights the clinical relevance of understanding this connection.
• Further research is essential to fully elucidate the complex mechanisms underlying the association between allergic diseases and SD.