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Cell Sheet Technology: An Emerging Approach for Tendon and Ligament Tissue Engineering
Yexin Li1, Ting Deng1, Dilihumaer Aili2
1Department of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Annals of Biomedical Engineering
|September 21, 2023
Summary
Cell sheet technology offers a promising approach for regenerating tendon and ligament tissues, addressing their limited healing capacity. This review explores its preclinical success in promoting healing and reducing inflammation for musculoskeletal injuries.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Musculoskeletal Research
Background:
- Tendon and ligament injuries are common musculoskeletal disorders with limited natural regenerative capacity.
- Current treatments face challenges in fully restoring native tissue structure and function.
- Cell sheet technology presents an innovative strategy for tissue engineering and regenerative medicine.
Purpose of the Study:
- To review the application of cell sheet technology in treating tendon and ligament injuries.
- To summarize advancements in stem cell-derived sheets for musculoskeletal tissue regeneration.
- To discuss challenges and future directions for clinical translation.
Main Methods:
- Review of preclinical studies on cell sheet technology for tendon and ligament repair.
- Summary of cell sheet harvesting procedures and their advantages.
- Analysis of stem cell-derived sheets' effects on inflammation and healing.
Main Results:
- Cell sheet technology preserves cell-to-cell connections and extracellular matrix, crucial for tissue regeneration.
- Preclinical studies demonstrate efficacy of stem cell-derived sheets in mitigating inflammation and enhancing tendon/graft-bone healing.
- Successful application in animal models for tendon and ligament injury repair.
Conclusions:
- Cell sheet technology shows significant potential for treating tendon and ligament injuries.
- Future clinical translation requires optimized cell sources, preparation processes, and animal models.
- Development of vascularized complex tissues using cell sheet technology is essential for clinical success.
