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Germ cells do not progress through spermatogenesis in the infertile zebrafish testis
Andrea L Sposato1, Darren R Llewellyn1, Jenna M Weber1
1School of Biological Sciences, University of Utah, Salt Lake City, UT 84112.
Biorxiv : the Preprint Server for Biology
|September 21, 2023
Summary
Aging male zebrafish testes show reduced germ cells and increased immune cells, impacting fertility. This study maps molecular changes during male fertility decline.
Area of Science:
- Reproductive Biology
- Developmental Biology
- Genomics
Background:
- Spermatogonial stem cells are crucial for lifelong sperm production.
- Male fertility declines with age, but underlying mechanisms are unclear.
- Previous studies relied on morphology, limiting molecular insights into spermatogenesis.
Conclusions:
- The study provides a comprehensive atlas of zebrafish testis development and aging.
- Age-related infertility is associated with germ cell loss and immune cell infiltration.
- The identified molecular roadmap can guide future research on male reproductive health.
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