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Updated: Jul 16, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
Lugdunin production and activity in Staphylococcus lugdunensis isolates are associated with its genotypes
Shih-Cheng Chang1,2, Cheng-Yen Kao3, Lee-Chung Lin1
1Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital , Taoyuan, Taiwan.
Importance:
Lugdunin is active against both methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci by dissipating their membrane potential. However, the association of lugdunin activity with the genotypes of Staphylococcus lugdunensis has not been addressed. Here, we show the high prevalence of lugdunin-producing strains among ST1 (83.3%), ST2 (66.7%), and ST3 (53.3%) S. lugdunensis. Moreover, we identified the antibacterial activity of lugdunin-producing strains against VISA and hVISA. These results shed light on the potential application of lugdunin for the treatment of drug-resistant pathogens.
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