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Related Experiment Video

Updated: Jul 16, 2025

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
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Responsive Nucleic Acid-Based Organosilica Nanoparticles.

Pierre Picchetti1, Stefano Volpi2, Marianna Rossetti3

  • 1Karlsruhe Institute of Technology (KIT), Institute of Nanotechnology (INT), Hermann-von-Helmholtz Platz 1, Eggenstein-Leopoldshafen 76344, Germany.

Journal of the American Chemical Society
|September 21, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed smart organosilica nanoparticles (NPs) by embedding synthetic nucleic acids. These biocompatible NPs offer tunable, multiresponsive properties for advanced drug delivery and sensing applications.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biochemistry

Background:

  • Smart nanoparticles (NPs) offer potential for advanced drugs, vaccines, and diagnostics.
  • Current nanocarrier development is limited by challenges in synthesizing responsive building blocks.
  • Biocompatible, multiresponsive nanocarriers are highly desirable for diverse applications.

Purpose of the Study:

  • To develop novel organosilica nanoparticles (NPs) with embedded synthetic nucleic acids.
  • To create multifunctional nanocarriers with tunable, multiresponsive behavior.
  • To leverage nucleic acid programmability and sol-gel chemistry for NP synthesis.

Main Methods:

  • A nature-inspired, one-step bottom-up approach combining nucleic acid chemistry and sol-gel processes.
  • Covalent incorporation of single-stranded nucleic acids into an organosilica framework.
  • Synthesis of organosilica NPs containing functional nucleic acids.

Main Results:

  • Successfully prepared organosilica NPs with covalently embedded nucleic acids.
  • Demonstrated that the functional nucleic acids enable NP responsiveness to biological, physical, and chemical inputs.
  • Observed detectable physicochemical changes in the NPs upon stimulation.

Conclusions:

  • The developed organosilica NPs are multifunctional systems combining oligonucleotide tunability with silica properties.
  • This approach offers a cost-effective, biocompatible platform for advanced applications.
  • The smart NPs show promise for drug delivery, diagnostics, and sensing.