Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

2.2K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.2K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

4.6K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.6K
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

473
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
473
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

1.9K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
1.9K
Bone Disorders01:29

Bone Disorders

3.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vasoactive Intestinal Peptide: Another Player in Adipose Tissue Blood Flow Regulation?

Microcirculation (New York, N.Y. : 1994)·2025
Same author

Glucagon-like peptide-1 is involved in fasting and postprandial blood flow regulation of subcutaneous adipose tissue.

Diabetes, obesity & metabolism·2025
Same author

Could Overt Diabetes Be Triggered by Abuse of Selective Androgen Receptor Modulators and Growth Hormone Secretagogues? A Case Report and Review of the Literature.

Clinical diabetes : a publication of the American Diabetes Association·2022
Same author

Letter to the Editor from Brunerová et al: "Association of Cognitive Function and Retinal Neural and Vascular Structure in Type 1 Diabetes".

The Journal of clinical endocrinology and metabolism·2021
Same author

Regulation of blood flow in adipose tissue: involvement of the cholinergic system.

American journal of physiology. Endocrinology and metabolism·2015
Same author

Measurement and manipulation of human adipose tissue blood flow using xenon washout technique and adipose tissue microinfusion.

Methods in enzymology·2014

Related Experiment Video

Updated: Jul 16, 2025

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

1.9K

Hypoparathyroidism.

Richard Sotorník

    Casopis Lekaru Ceskych
    |September 21, 2023
    PubMed
    Summary

    Hypoparathyroidism, a rare endocrine disorder, causes low calcium due to parathormone deficiency. Current treatments are insufficient, and the only recombinant parathormone drug is recalled, highlighting the need for better therapies.

    Area of Science:

    • Endocrinology
    • Rare Diseases

    Background:

    • Hypoparathyroidism results from parathormone deficiency, leading to hypocalcemia and neuromuscular symptoms.
    • Conventional treatment with calcium and vitamin D has limitations and may cause chronic complications.
    • The only available recombinant parathormone drug is being recalled, creating a treatment gap.

    Purpose of the Study:

    • To review the challenges in managing hypoparathyroidism.
    • To discuss the limitations of current treatments.
    • To highlight the unmet need for effective parathormone replacement therapy.

    Main Methods:

    • Literature review of hypoparathyroidism pathophysiology and treatment.
    • Analysis of current therapeutic strategies and their drawbacks.
    • Evaluation of the impact of recombinant parathormone drug recall.
    Keywords:
    calciumhypocalcemiahypoparathyroidismparathormonephosphatephosphorusvitaminvitamin D

    More Related Videos

    Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
    07:12

    Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

    Published on: August 17, 2022

    3.5K
    Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
    07:13

    Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

    Published on: March 14, 2017

    14.6K

    Related Experiment Videos

    Last Updated: Jul 16, 2025

    Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
    03:57

    Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

    Published on: July 14, 2023

    1.9K
    Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
    07:12

    Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

    Published on: August 17, 2022

    3.5K
    Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
    07:13

    Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

    Published on: March 14, 2017

    14.6K

    Main Results:

    • Parathormone deficiency causes significant neuromuscular issues.
    • Standard treatments inadequately replace parathormone and carry risks.
    • The recall of recombinant parathormone exacerbates treatment challenges.

    Conclusions:

    • Effective management of hypoparathyroidism remains a clinical challenge.
    • There is a critical need for novel and accessible parathormone replacement therapies.
    • Judicious thyroidectomy is key for preventing hypoparathyroidism.