Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protection from venous air embolism with fluorocarbon emulsion FC-43.

B D Spiess, R McCarthy, D Piotrowski

    The Journal of Surgical Research
    |October 1, 1986
    PubMed
    Summary

    Perfluorocarbon emulsion FC-43 significantly prolonged survival in rabbits experiencing venous air embolism (VAE). This artificial oxygen carrier improved hemodynamics and gas exchange during VAE events.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Three-dimensional high-resolution anorectal manometry in children after surgery for anorectal disorders.

    European review for medical and pharmacological sciences·2021
    Same author

    Upper Limits on the Stochastic Gravitational-Wave Background from Advanced LIGO's First Observing Run.

    Physical review letters·2017
    Same author

    Prospects for Observing and Localizing Gravitational-Wave Transients with Advanced LIGO and Advanced Virgo.

    Living reviews in relativity·2017
    Same author

    Inclined to agree with tabloid opinions.

    Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2016
    Same author

    Standardised versus Individualised Parenteral Nutrition. Further Food for Thought.

    Irish medical journal·2016
    Same author

    Evidence for a B_{s}^{0}π^{±} State.

    Physical review letters·2016

    Area of Science:

    • Anesthesiology
    • Cardiovascular Surgery
    • Critical Care Medicine

    Background:

    • Intraoperative venous air embolism (VAE) poses significant hemodynamic risks.
    • Perfluorocarbon emulsions offer potential as artificial oxygen carriers with unique properties.
    • FC-43 is a perfluorocarbon emulsion investigated for its therapeutic potential.

    Purpose of the Study:

    • To evaluate the efficacy of FC-43 as a volume expander in mitigating the effects of venous air embolism (VAE).
    • To compare FC-43 with other volume expanders in a rabbit model of VAE.

    Main Methods:

    • 91 New Zealand White rabbits were subjected to continuous femoral venous air infusion after anesthesia and mechanical ventilation.
    • Animals received FC-43 or other volume expanders (20 cc/kg over 30 min) prior to air infusion.

    Related Experiment Videos

  • Hemodynamic parameters (arterial pressure, central venous pressure, ECG) and blood gases were monitored until death.

    • Main Results:

    • FC-43 administration significantly prolonged survival time in rabbits exposed to VAE (P < 0.05).
    • Animals treated with FC-43 exhibited higher partial pressures of oxygen (PaO2 and PvO2).
    • FC-43 group showed lower central venous pressure during air embolism compared to control groups.

    Conclusions:

    • FC-43 as a volume expander enhances survivability during venous air embolism in a rabbit model.
    • FC-43 may improve oxygenation and reduce hemodynamic compromise associated with VAE.
    • Further investigation is warranted to elucidate the mechanisms behind FC-43's protective effects.