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Updated: Jul 16, 2025
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Establishing a Device for Sleep Deprivation in Mice
Published on: September 22, 2023
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Sleep deprivation and aging are metabolically linked across tissues
Arjun Sengupta1, Jennifer C Tudor2,3, Danielle Cusmano2
1Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sleep
|September 22, 2023
Summary
Sleep deprivation (SD) causes aging-like effects on learning and memory. This study found that acute sleep deprivation in mice induces metabolic changes similar to aging, particularly in the liver and plasma.
Area of Science:
- Metabolomics
- Neuroscience
- Aging Research
Background:
- Sleep deprivation (SD) is linked to neurodegenerative and cardiometabolic diseases.
- SD can accelerate cognitive decline, mimicking aging processes.
- The molecular links between SD and aging remain largely unexplored.
Purpose of the Study:
- To investigate the common molecular underpinnings of sleep deprivation and aging.
- To profile metabolic changes in response to acute SD in young and aged mice.
- To identify a metabolic signature associated with sleep loss and aging.
Main Methods:
- Acute sleep deprivation (5 hours) was applied to young adult and aged mice.
- Metabolic profiling of blood plasma, hippocampus, and liver was performed using UPLC-MS/MS.
- Comparative analysis of metabolic profiles based on age and sleep status.
Main Results:
- Sleep deprivation primarily affected peripheral plasma and liver metabolism, including ketone body and nicotinamide pathways.
- Aging had a more pronounced impact on hippocampal metabolism.
- Aged mice exhibited baseline metabolic features resembling those of sleep-deprived young mice.
- A distinct set of nine metabolites could classify animals based on age and sleep status with 79% accuracy.
Conclusions:
- Metabolic alterations induced by sleep deprivation show significant parallels with aging processes.
- This study defines a molecular metabolic signature for sleep loss and aging.
- Findings suggest that sleep deprivation can induce aging-like metabolic changes.
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