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Updated: Jul 8, 2026

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

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Distinct roles of telomerase activity in age-related chronic diseases: An update literature review

Xiaodan Wang1, Hao Deng1, Jingyi Lin1

  • 1Medical Experiment Center, Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 300381 Tianjin, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|September 22, 2023
PubMed

Keywords:
Age-related degenerative diseasesAgingTelomerase activityTherapeutic prospect

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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
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