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Related Experiment Video

Updated: Jul 16, 2025

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration

Published on: November 23, 2019

4D Monte Carlo dose reconstructions using surface motion measurements.

Meaghen Shiha¹, Joanna E Cygler², Robert MacRae³

¹Department of Physics, Carleton University, Ottawa, ON K1S 5B6, Canada.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)

|September 22, 2023

Summary

This study demonstrates a feasible 4D Monte Carlo method for reconstructing VMAT doses, assessing respiratory motion impact in lung cancer patients. The method accurately captured dose variations due to breathing motion.

Keywords:

4D Monte Carlo Dose reconstruction Log files Lung

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Area of Science:

Medical Physics
Radiation Oncology

Background:

Respiratory motion significantly impacts dose delivery accuracy in lung cancer radiotherapy.
Accurate dose reconstruction is crucial for understanding and mitigating motion-related uncertainties in VMAT treatments.

Purpose of the Study:

To evaluate the feasibility of a 4D Monte Carlo (MC) dose reconstruction method.
To assess the dosimetric impact of respiratory motion using surface measurements in Non-Small Cell Lung Cancer (NSCLC) patients undergoing VMAT.

Main Methods:

Utilized the 4Ddefdosxyznrc/EGSnrc algorithm for dose reconstruction from machine log files and RADPOS 4D dosimetry system data.
Generated patient-specific respiratory models from 4DCT images and surface motion traces.
Compared reconstructed doses with planned doses calculated on average-intensity and exhale-phase CT images.

Main Results:

Successfully implemented the 4D dose reconstruction method for two NSCLC patients over five fractions.
Observed predominantly anterior/posterior respiratory motion (8.7-10.0 mm amplitude) with inter- and intra-fractional variations.
Found small inter-fractional differences in reconstructed doses, attributed to organ volume variations.

Conclusions:

The 4D MC dose reconstruction method is feasible for VMAT treatments in NSCLC patients.
The study highlights the potential for surface motion surrogates to account for breathing effects in dose reconstruction.