Related Experiment Video
Updated: Jul 16, 2025
08:42
Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
Published on: May 19, 2015
10.8K
Functional dysconnectivity in youth depression: Systematic review, meta-analysis, and network-based integration
Nga Yan Tse1, Aswin Ratheesh2, Saampras Ganesan3
1Melbourne Neuropsychiatry Centre, Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Australia.
Neuroscience and Biobehavioral Reviews
|September 22, 2023
Summary
Youth depression involves widespread brain connectivity issues, particularly in key networks like the default mode and limbic systems. These findings suggest similar neurobiological roots for depression in both adolescents and adults.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Youth depression exhibits varied brain connectivity patterns.
- Previous research shows heterogeneous findings in aberrant brain connectivity in adolescents with depression.
Purpose of the Study:
- To systematically review and meta-analyze resting-state fMRI studies on brain connectivity in youth depression.
- To clarify divergent findings by examining connectivity within canonical brain networks.
Main Methods:
- Systematic review of 19 resting-state fMRI seed-to-whole-brain studies.
- Meta-analyses of connectivity in default-mode, limbic networks, and amygdala.
- Integration of region-to-region dysconnectivity within distributed brain networks.
Main Results:
- Broad and distributed anatomical findings in youth depression.
- Dysconnectivity centered on central executive, default mode, salience, and limbic networks.
- Convergence with adult depression literature, suggesting shared neurobiology.
Conclusions:
- Youth depression is characterized by widespread network dysconnectivity.
- Neurobiological underpinnings of youth and adult depression appear similar.
- Network-level analysis clarifies complex connectivity abnormalities.
Related Concept Videos
01:18Depression: Overview
271
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
271
01:27Depressive Disorders: Etiology
114
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
114
01:27Depressive Disorders: MDD and Dysthymia
149
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
149
01:03Long-term Depression
2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.6K
01:30Attention-Deficit/Hyperactivity Disorder
85
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
85
01:27Dissociative Disorders
136
Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
136