FEATURES OF BONE REMODELING AROUND SURFACE-MODIFIED TITANIUM AND TANTALUM IMPLANTS

The aim: To study the osseointegrative properties of titanium and tantalum implants with different surface structures in animal experiments.

Materials and methods: The histological and morphometric study was carried out on 60 male white rats after titanium implants with different surface structures made by 3D printed technology were inserted in the distal femur bone: presented by the multilayered layers of interlacing pores of 300 microns (series 1); rough (> 2 microns) (series 2); and tantalum implants with 300 microns pores and 80% porosity (series 3) as control material.

Results: On the 30 days we found statistically significant differences in the bone-implant contact rate between the 2nd experiment series (44.77 ± 1.86)% and 1st (59.91 ± 2.86)% (p=0.000047) and 3rd (53.89 ± 2.11)% (р=0.000065), on the 90 days between the 2nd experiment series (51.26 ± 2.7)% and 1st (66.84 ± 2.63)% (p=0.000187) and 3rd (70.35 ± 4.32)% (p=0.000349). There was a difference between the indices of the bone-implant volume at day 90 between the 1st (48.43 ± 2.2)% and 2nd (36.88 ± 2.56)% series (p=0.000919), between the 2nd and 3rd series (51.2 ± 3.06)% (p=0.000107). There were no significant differences between the studied indices in the 1st and 3rd series of the experiment.

Conclusions: Titanium implants with multilayered interlaced pore layers of 300 microns and tantalum with 300 microns pore size and 80% porosity may be promising. Rough-surface titanium also has osseointegrative qualities, but they are lower compared to other materials.