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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
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Aerobic physical exercise modifies the prostate tumoral environment
Allice Santos Cruz Veras1, Rafael Ribeiro Correia1, Victor Rogério Garcia Batista1
1Multicenter Graduate Program in Physiological Sciences, SBFis, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil.
Life Sciences
|September 23, 2023
Summary
Aerobic exercise significantly reduces prostate cancer progression by decreasing cell proliferation and inflammation. This physical activity enhances antioxidant defenses and modulates key proteins, offering a beneficial approach to cancer control.
Area of Science:
- Oncology
- Exercise Physiology
- Molecular Biology
Background:
- Exercise is linked to reduced cancer risk, but underlying molecular mechanisms require elucidation.
- Oxidative stress and inflammation are implicated in cancer development and progression.
- Understanding exercise's impact on these factors is crucial for cancer prevention and treatment strategies.
Purpose of the Study:
- To investigate the hypothesis that aerobic exercise attenuates prostate cancer (PC) by modulating oxidative stress and inflammation.
- To examine the effects of a structured aerobic exercise regimen on tumor growth, cell proliferation, apoptosis, and inflammatory markers in a rat model of prostate cancer.
Main Methods:
- Twenty male Sprague Dawley rats with chemically induced prostate tumors were divided into control (PC) and exercise (PC + Ex) groups.
- The PC + Ex group underwent 8 weeks of treadmill exercise (5 sessions/week, 60% max capacity).
- Analyses included body weight, feed efficiency, Ki-67 (proliferation marker), apoptosis markers, oxidative stress indicators, and cytokine levels (IL-10, IL-6, TNF-α, NF-κB).
Main Results:
- Aerobic exercise significantly reduced prostate cell proliferation (Ki-67), tumor size, and prostate weight (p < 0.05).
- Exercise modulated apoptosis, decreasing anti-apoptotic protein expression and increasing pro-apoptotic protein expression (p < 0.05).
- Significant improvements were observed in antioxidant defenses, reduced lipid peroxidation and protein carbonyls, and altered inflammatory profiles (increased IL-10, decreased IL-6, TNF-α, NF-κB) in the exercise group.
Conclusions:
- Aerobic physical exercise is an effective approach for controlling prostate cancer progression.
- Exercise exerts anti-inflammatory and antioxidant effects by modulating systemic factors, including glucose and lipid metabolism.
- These modifications create an environment that attenuates tumor growth and offers a functional, beneficial strategy for cancer management.
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