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High-sensitivity cardiac troponin I for cardiovascular risk stratification in apparently healthy individuals

Dimitrios Farmakis1, Dimitrios Richter2, Genovefa Chronopoulou3

  • 1Department of Cardiology, Attikon University Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Hellenic Journal of Cardiology : HJC = Hellenike Kardiologike Epitheorese
|September 24, 2023
PubMed

Insights

High-sensitivity cardiac troponin (hs-cTn) assays detect low troponin levels in healthy individuals. This biomarker aids in predicting cardiovascular events and mortality, enhancing risk assessment in primary prevention.

Area of Science:

  • Cardiology
  • Biomarkers
  • Preventive Medicine

Background:

  • Cardiac troponins (Troponin I and T) are vital for diagnosing acute coronary syndromes.
  • They also serve as independent predictors for various clinical conditions.
  • High-sensitivity assays (hs-cTn) detect minute troponin concentrations in asymptomatic individuals.

Purpose of the Study:

  • To summarize evidence on hs-cTnI's role in predicting cardiovascular events and mortality in healthy individuals.
  • To evaluate the additive value of hs-cTnI to existing risk stratification methods.
  • To provide guidance for integrating hs-cTnI into cardiovascular prevention strategies.

Main Methods:

  • Systematic review and evidence synthesis by a panel of Greek experts.
  • Focus on studies involving apparently healthy and asymptomatic individuals.
  • Analysis of hs-cTnI's predictive capabilities and its incremental value over standard risk factors.

Main Results:

  • hs-cTnI is a strong predictor of cardiovascular events and mortality in the general population.
  • It offers additive value beyond established risk stratification tools.
  • Low concentrations of hs-cTnI in apparently healthy individuals indicate increased risk.

Conclusions:

  • hs-cTnI is a promising tool for cardiovascular risk stratification in apparently healthy individuals.
  • Its incorporation into preventive strategies can improve cardiovascular risk assessment.
  • Further research and clinical guidelines are needed for widespread adoption.

Keywords:
cardiovascular riskgeneral populationhigh-sensitivity cardiac troponin Irisk stratificationtroponin

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