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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
Published on: March 25, 2016
[Association between maternal immune activation and neurodevelopmental disorders in children]
1Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University/Key Laboratory of Population Health Across Life Cycle, Ministry of Education/Anhui Province Key Laboratory of Population Health and Aristogenics/National Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei 230032, China.
During pregnancy, as a special period, mother is vulnerable to adverse exposure, affecting the health of offspring. Maternal immune activation (MIA) due to maternal immune imbalance during pregnancy can affect the neurodevelopment of offspring. Evidence from epidemiological studies and animal studies supports an association between MIA and neurodevelopmental disorders (NDDs) in offspring. A variety of factors, such as genetic background, maternal nutritional status and maternal gut microbes, can influence the strength of the association. Studies have shown that MIA affects synapsis formation and pruning in offspring through a variety of pathways, and the placenta also plays a role in such association. This article summarizes the recent research of the association between MIA and neurodevelopmental disorders in children, and provides suggestion for the prevention of the incidence of NDDs.
During pregnancy, as a special period, mother is vulnerable to adverse exposure, affecting the health of offspring. Maternal immune activation (MIA) due to maternal immune imbalance during pregnancy can affect the neurodevelopment of offspring. Evidence from epidemiological studies and animal studies supports an association between MIA and neurodevelopmental disorders (NDDs) in offspring. A variety of factors, such as genetic background, maternal nutritional status and maternal gut microbes, can influence the strength of the association. Studies have shown that MIA affects synapsis formation and pruning in offspring through a variety of pathways, and the placenta also plays a role in such association. This article summarizes the recent research of the association between MIA and neurodevelopmental disorders in children, and provides suggestion for the prevention of the incidence of NDDs.
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