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Updated: Aug 15, 2026
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Modeling Amyloid-β42 Toxicity and Neurodegeneration in Adult Zebrafish Brain
Published on: October 25, 2017
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Finding Drug Repurposing Candidates for Neurodegenerative Diseases using Zebrafish Behavioral Profiles
Thaís Del Rosario Hernández1, Sayali V Gore1, Jill A Kreiling1
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, USA.
Biorxiv : the Preprint Server for Biology
|September 25, 2023
Summary
This study used a zebrafish model and AI to screen existing drugs for potential Alzheimer's disease treatments. Researchers identified 64 promising drug candidates for neurodegenerative disorders.
Area of Science:
- Neuroscience
- Pharmacology
- Artificial Intelligence
Background:
- Drug repurposing offers a cost-effective alternative to de novo drug design for diseases like Alzheimer's.
- Zebrafish larvae models are valuable for studying cognitive function and screening therapeutics.
- Calcineurin inhibitors, like Cyclosporine (CsA), show potential for Alzheimer's disease prevention.
Conclusions:
- Drug repurposing using AI-driven behavioral analysis in zebrafish is a viable strategy for discovering neurodegenerative disease therapeutics.
- The identified 64 drug candidates warrant further investigation for Alzheimer's disease and other neurodegenerative conditions.
- This approach accelerates the identification of potential treatments for disorders with unmet medical needs.
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