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Genetic Variants That Modify the Neuroendocrine Regulation of Foraging Behavior in C. elegans.

Harksun Lee1, Sonia A Boor1,2, Zoë A Hilbert2

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Summary

Natural genetic variations in the C. elegans gene gap-2 influence the expression of the neuroendocrine TGF-beta ligand DAF-7. This impacts exploratory foraging behavior, linking gene expression to behavioral diversity.

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Area of Science:

  • Neuroscience
  • Genetics
  • Animal Behavior

Background:

  • Understanding the genetic basis of behavioral diversity is crucial.
  • The neuroendocrine TGF-beta ligand DAF-7 in C. elegans influences responses to food and pathogens.
  • DAF-7 expression in neurons is dynamically regulated by bacterial cues.

Approach:

  • Investigated natural variation in DAF-7 expression in ASJ chemosensory neurons.
  • Identified variants in the gap-2 gene, encoding a GTPase-Activating Protein.
  • Examined the cell-non-autonomous modification of DAF-7 expression by gap-2 variants.

Key Points:

  • Common gap-2 variants were identified that modify DAF-7 expression.
  • gap-2 variants promote exploratory foraging behavior in a DAF-7-dependent manner.
  • This study connects natural variation in neuron-specific gene expression to behavioral differences.

Conclusions:

  • Genetic variation in gap-2 influences DAF-7 expression and foraging behavior.
  • Suggests neuroendocrine signaling pathways mediating host-microbe interactions contribute to behavioral diversity.
  • Highlights the role of genetic variation in neuronal gene expression for behavioral traits.