Related Experiment Video

Updated: Jul 15, 2025

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
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SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

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Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease

Mario Nieto1,2, Mina Konigsberg2, Alejandro Silva-Palacios3

  • 1Department of Cardiovascular Biomedicine, National Institute of Cardiology, Ignacio Chávez, Juan Badiano No. 1. Colonia Sección XVI, 14080, Mexico City, Mexico.

Biogerontology
|September 25, 2023
PubMed

Insights

Cellular senescence drives aging diseases. Senolytics, like dasatinib and quercetin, clear senescent cells, offering potential therapies for age-related heart disease and myocardial damage.

Area of Science:

  • Gerontology and Cardiology
  • Cellular Biology and Pathology

Background:

  • Cellular senescence contributes to aging and age-associated diseases.
  • Senescent cells accumulate in the heart, exacerbating cardiovascular disease (CVD).

Purpose of the Study:

  • To review the role of senescent cells in the aging heart and CVD.
  • To discuss senolytics as potential therapies for myocardial damage.

Main Methods:

  • Literature review focusing on cellular senescence, aging heart, and senolytics.
  • Discussion of specific senolytics, including dasatinib and quercetin.
  • Analysis of mechanisms and physiological effects of senolytics in aged hearts.

Main Results:

  • Senescent cells are implicated in age-related cardiac pathologies.
  • Senolytics demonstrate potential in preventing myocardial damage progression.
  • Dasatinib and quercetin show promise in senolytic therapy for the aging heart.

Conclusions:

  • Targeting cellular senescence with senolytics is a promising strategy for treating age-related cardiovascular disease.
  • Senolytic therapies may offer accessible and safe treatment options for myocardial damage.
Keywords:
Aged heartApoptosisCardiovascular diseaseDasatinibQuercetinSenolytics

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