Related Experiment Video
Updated: Jul 15, 2025

Author Spotlight: Establishing a Practical and Cost-Effective Protocol for Corneal Sensitivity Testing in Clinical Settings
Published on: August 2, 2024
Evaluation of ocular neuropathic pain
Damien Tuan-Man Le1, Himal Kandel1, Stephanie L Watson1
1The University of Sydney, Save Sight Institute, Sydney, NSW, 2000, Australia; Sydney Eye Hospital, Sydney, NSW, 2000, Australia.
Validated questionnaires can help diagnose ocular neuropathic pain. Disease-specific tools are limited, while general ophthalmic questionnaires lack reliability for evaluating ocular pain.
Area of Science:
- Ophthalmology
- Pain Management
- Psychometrics
Background:
- Ocular neuropathic pain diagnosis requires validated assessment tools.
- Current questionnaires vary in quality and applicability.
- Identifying reliable instruments is crucial for accurate evaluation.
Purpose of the Study:
- To identify and assess the quality of validated questionnaires for ocular neuropathic pain.
- To evaluate the psychometric properties and reliability of existing instruments.
- To review associated etiological factors and clinical associations.
Main Methods:
- Comprehensive literature search across multiple databases (MEDLINE, PubMed, EMBASE, PsycINFO, Cochrane Library).
- Inclusion of articles evaluating questionnaires for ocular neuropathic pain and its causes.
- Extraction and quality assessment of data on psychometric properties, validity, and reliability.
Main Results:
- 61 publications covering 28 questionnaires met inclusion criteria.
- The Contact Lens Discomfort Index (CLDI) showed the highest psychometric properties.
- Disease-specific questionnaires were appropriate for their populations, but non-disease-specific ones lacked reliability.
- The English Ocular Comfort Index (OCI) provided extensive psychometric data.
Conclusions:
- Ocular pain questionnaires show potential for diagnosing neuropathic pain.
- Disease-specific questionnaires are limited to their target populations.
- Non-disease-specific ophthalmic questionnaires demonstrated poor reliability and validity.
- Further research is needed to identify the optimal questionnaire for ocular neuropathic pain.
Related Concept Videos
Glaucoma: Overview
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Local Anesthetics: Differential Sensitivity of Nerve Fibers

