Related Experiment Video

Updated: Jul 15, 2025

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

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Adjuvant therapy for renal cell carcinoma: A systematic review of current landscape and future directions

Hatice Bolek1, Yüksel Ürün1

  • 1Department of Medical Oncology, Ankara University School of Medicine, Ankara, Turkey; Ankara University Cancer Research Institute, Ankara, Turkey.

Critical Reviews in Oncology/Hematology
|September 25, 2023
PubMed

Insights

New treatments like tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) show promise for advanced kidney cancer after surgery. Further research is needed to improve risk prediction and find better biomarkers for adjuvant renal cell carcinoma (RCC) treatment.

Area of Science:

  • Oncology
  • Translational Medicine
  • Clinical Trials

Background:

  • Advanced renal cell carcinoma (RCC) treatment has been revolutionized by tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs).
  • The efficacy of these agents in the adjuvant setting post-surgical resection is still under investigation and debated.
  • Current risk stratification methods predate the TKI/ICI era and lack predictive accuracy for relapse.

Conclusions:

  • The current landscape of adjuvant renal cell carcinoma (RCC) treatment necessitates improved risk stratification beyond existing models.
  • Further investigation into novel biomarkers is crucial for optimizing patient selection and predicting outcomes with TKIs and ICIs.
  • Future research should focus on refining adjuvant therapeutic strategies to enhance patient outcomes in advanced RCC.
Keywords:
AdjuvantRenal cell carcinomaTyrosine kinase inhibitor, immune checkpoint inhibitor

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