Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Bone Disorders01:29

Bone Disorders

3.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.6K
Longitudinal Research02:20

Longitudinal Research

12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K
Aging01:26

Aging

72
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
72
Menopause01:28

Menopause

191
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
191
Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

73
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
73

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Change of sexual activity and its relation to the quality of life in older people: Cognition of Older People, Education, Recreational Activities, NutritIon, Comorbidities, fUnctional Capacity Studies (COPERNICUS).

Maturitas·2026
Same author

Low- and no-calorie sweeteners and beverages and their associated health outcomes: an umbrella review of systematic reviews and meta-analyses.

Nutrition research and practice·2026
Same author

What hospital quality indicators matter to patients? Results from a general population survey.

The European journal of health economics : HEPAC : health economics in prevention and care·2026
Same author

Current use of specific wearables and factors that would motivate future use of wearables: Results based on the general German adult population.

PloS one·2026
Same author

Temporal trends and patterns in neonatal sepsis mortality across 194 countries, 2000-2021, with projections up to 2050.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Machine Learning Prediction Model for Dyslipidemia and Its Association With Atherothrombotic Events in 3 Independent Cohorts From South Korea, Japan, and the United Kingdom: Algorithm Development and Validation Study.

JMIR medical informatics·2026
Same journal

The Embedded Model for Bridging Essential Delivery of Care in Assisted Living Facilities-EMBED-ALF.

Journal of the American Medical Directors Association·2026
Same journal

Opportunities for Improving End-of-Life Care for Veterans Receiving Hospice in Community Nursing Homes.

Journal of the American Medical Directors Association·2026
Same journal

The Association Between Relocations and Health Outcomes in Nursing Home Residents: A Retrospective Cohort Study.

Journal of the American Medical Directors Association·2026
Same journal

Patient-Driven Grouping Model and Home Health Use Among Traditional Medicare Beneficiaries.

Journal of the American Medical Directors Association·2026
Same journal

Accuracy of Language Data in Home Care and Long-Term Care Assessments in Ontario, Canada.

Journal of the American Medical Directors Association·2026
Same journal

Cybercycling Training Among 582 Institutionalized Older Adults: A Real-World Multicohort Retrospective Study.

Journal of the American Medical Directors Association·2026
See all related articles

Related Experiment Video

Updated: Jul 15, 2025

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

5.9K

Factors Leading to a Decrease in Grip Strength Among the Oldest Old: A Large, Representative, Longitudinal Survey.

André Hajek1, Hans-Helmut König1

  • 1Department of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Germany.

Journal of the American Medical Directors Association
|September 25, 2023
PubMed
Summary
This summary is machine-generated.

Among older adults, grip strength declines with age and worsening self-rated health. Maintaining social connections can help preserve grip strength, crucial for overall health and longevity.

Keywords:
Grip strengthdepressionfrailtylonelinessself-rated healthsocial network

More Related Videos

Measurement of Spatial Stability in Precision Grip
09:36

Measurement of Spatial Stability in Precision Grip

Published on: June 4, 2020

3.2K
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

12.6K

Related Experiment Videos

Last Updated: Jul 15, 2025

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

5.9K
Measurement of Spatial Stability in Precision Grip
09:36

Measurement of Spatial Stability in Precision Grip

Published on: June 4, 2020

3.2K
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

12.6K

Area of Science:

  • Gerontology
  • Public Health
  • Sociology

Background:

  • Grip strength is a key indicator of physical performance and health in older adults.
  • Limited research exists on factors influencing grip strength in the oldest old, especially in large, representative samples including institutionalized individuals.

Purpose of the Study:

  • To investigate factors associated with grip strength in individuals aged 80 and above.
  • To address the knowledge gap regarding grip strength determinants in the very old population.

Main Methods:

  • A large-scale, representative, longitudinal study design was employed.
  • Data were collected from 1824 individuals aged 80+ in North Rhine-Westphalia, including those in institutionalized settings and private households.
  • Isometric grip strength was measured using a dynamometer.

Main Results:

  • Decreases in grip strength were significantly associated with increasing age (β = -0.70, P < .001).
  • Reduced social network size (β = 0.08, P < .05) and worsening self-rated health (β = 0.80, P < .01) were also significantly linked to decreased grip strength.
  • No significant associations were found between grip strength changes and marital status, living situation, number of chronic conditions, depressive symptoms, or health literacy.

Conclusions:

  • Longitudinal data confirm that age, social network size, and self-rated health are associated with grip strength in the oldest old.
  • Identifying individuals at risk for low grip strength is possible through these factors.
  • Maintaining social contacts may be a beneficial strategy to preserve grip strength, which is linked to better quality of life, function, cognition, and longevity.