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Updated: Jul 15, 2025

Paradigms of Lower Extremity Electrical Stimulation Training After Spinal Cord Injury
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Neuromuscular Electrical Stimulation for Intermittent Claudication (NESIC): multicentre, randomized controlled trial.

Laura Burgess1,2, Adarsh Babber1,2, Joseph Shalhoub1,2

  • 1Department of Surgery and Cancer, Imperial College London, London, UK.

The British Journal of Surgery
|September 25, 2023
PubMed
Summary
This summary is machine-generated.

Neuromuscular electrical stimulation (NMES) did not significantly improve walking distance for intermittent claudication overall. However, NMES showed benefits in mild cases, and supervised exercise therapy (SET) proved effective.

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Area of Science:

  • Vascular Surgery
  • Rehabilitation Medicine
  • Biomedical Engineering

Background:

  • Intermittent claudication (IC) significantly impacts quality of life and mobility.
  • Standard care for IC includes best medical therapy and supervised exercise therapy (SET).
  • Neuromuscular electrical stimulation (NMES) is a potential adjunctive therapy for improving walking capacity.

Purpose of the Study:

  • To evaluate the clinical efficacy of NMES in addition to standard care for improving walking distances in patients with IC.
  • To assess the impact of NMES on intermittent claudication distance, quality of life, and haemodynamic changes.

Main Methods:

  • An open, multicentre, randomized controlled trial involving 200 patients with IC.
  • Patients were randomized (1:1) to receive NMES plus standard care or standard care alone.
  • Primary outcome was the change in absolute walking distance at 3 months, measured by a standardized treadmill test.

Main Results:

  • Adjunctive NMES did not demonstrate a statistically significant improvement in overall walking distance at 3 months.
  • Supervised exercise therapy (SET) as standard care significantly improved walking distance compared to best medical therapy alone.
  • NMES showed a statistically significant improvement in walking distance for patients with mild IC.

Conclusions:

  • Supervised exercise therapy (SET) is an effective treatment for intermittent claudication.
  • NMES may offer additional benefits for patients with mild intermittent claudication.
  • No serious adverse events were reported with the use of the NMES device.