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Related Experiment Video

Updated: Jul 15, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Objective detection of visual field defects with multifrequency VEPs.

Katja Crux1, Cord Huchzermeyer1, Jan Kremers1

  • 1Department of Ophthalmology, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany.

Documenta Ophthalmologica. Advances in Ophthalmology
|September 25, 2023
PubMed
Summary

Multifrequency pattern reversal visual evoked potentials (VEPs) can reliably detect visual field losses in glaucoma patients. High signal-to-noise ratio (SNR) values in QmfrVEPs can exclude visual field defects.

Keywords:
Objective visual field testPattern reversalQuadrant multifrequency VEPSignal-to-noise ratioSteady state

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Visual Electrophysiology

Background:

  • Visual field loss is a key indicator of glaucoma, often detected through perimetry.
  • Objective electrophysiological methods are needed for sensitive and reliable visual field assessment.

Purpose of the Study:

  • To correlate multifrequency pattern reversal visual evoked potentials (VEPs) in quadrants (QmfrVEPs) with perimetric field losses.
  • To evaluate QmfrVEPs for objective detection of visual field losses in glaucoma patients.

Main Methods:

  • QmfrVEP measurements were performed monocularly in normal subjects and glaucoma patients using four LED-based checkerboard stimulators.
  • Discrete Fourier analysis identified responses to stimuli with slightly varied reversal frequencies (11.92-12.16 reversals/sec).
  • The highest signal-to-noise ratio (SNR) recording was used for analysis.

Main Results:

  • QmfrVEP responses from different quadrants were reliably measured and separated.
  • A significant correlation was found between SNR and perimetric visual field losses (Spearman rank correlation: P < 0.001).
  • Glaucoma patients showed reduced SNR in quadrants with perimetric defects, confirming the procedure's sensitivity.

Conclusions:

  • QmfrVEP responses are reliably measurable and can be used for objective assessment.
  • High SNR values in QmfrVEPs can exclude visual field defects.
  • Focal visual field defects in glaucoma patients can be identified using QmfrVEPs.