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Related Concept Videos

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Updated: Jul 15, 2025

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
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Simultaneous perfusion, diffusion, T2 *, and T1 mapping with MR fingerprinting.

Hongli Fan1,2, Lisa Bunker3, Zihan Wang1,2

  • 1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Magnetic Resonance in Medicine
|September 26, 2023
PubMed
Summary

This study introduces a new MRI technique using magnetic resonance fingerprinting (MRF) to simultaneously map brain perfusion, diffusion, T2*, and T1. This novel approach offers excellent image quality and is promising for stroke patients.

Keywords:
MR fingerprinting (MRF)arterial spin labelingarterial transit timecerebral blood flowdiffusionperfusionrelaxometrystroke

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Area of Science:

  • Neuroimaging
  • Magnetic Resonance Imaging (MRI)
  • Cerebrovascular Diseases

Background:

  • Quantitative mapping of brain perfusion, diffusion, T2*, and T1 is crucial for cerebrovascular disease diagnosis.
  • Current MRI techniques require separate sequences for each parameter, increasing scan time.

Purpose of the Study:

  • To develop a novel MRI technique for simultaneous estimation of perfusion, diffusion, T2*, and T1 parameters.
  • To reduce scan time and improve efficiency in multi-parametric brain mapping.

Main Methods:

  • A modified magnetic resonance fingerprinting (MRF) sequence, based on MRF-arterial spin labeling (ASL), was developed.
  • The sequence incorporated modified acquisition modules with varying echo times (TEs) and diffusion-weighting gradients.
  • Quantitative values were compared against reference methods (MRF-ASL, DWI, T2* mapping), and test-retest repeatability was assessed.

Main Results:

  • The novel method achieved a 24% reduction in scan time compared to separate sequences.
  • Parametric maps demonstrated excellent image quality with strong correlations to reference methods.
  • High reliability was observed for ADC, T2*, T1, and B1+ estimation (CoV <5%).
  • The technique successfully detected both ischemic and hemorrhagic stroke in initial patient applications.

Conclusions:

  • The proposed simultaneous multi-parametric mapping technique is a promising advancement in MRI.
  • This method has significant potential for clinical application in stroke patients, offering efficient and comprehensive brain assessment.