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Silver-based gels for oral and skin infections: antimicrobial effect and physicochemical stability
João Mc Silva1, Ana Bv Teixeira1, Andréa C Reis1
1Department of Dental Materials & Prosthesis, Ribeirão Preto Dental School, University of São Paulo, Avenida do Café s/n, Ribeirão Preto, São Paulo, 14040-904, Brazil.
Abstract:
Aim: To systematically evaluate the literature on silver (Ag) gels and their antimicrobial efficacy and physicochemical stability. Materials & methods: A search was performed in PubMed/MEDLINE, LILACS, Web of Science, Scopus, Embase and Google Scholar. Results: Gels were formulated with Ag nanoparticles, Ag oxynitrate and colloidal Ag and showed antimicrobial activity for concentrations ranging from 0.002 to 30%. Gels showed stability of their chemical components, and their physicochemical properties, including viscosity, organoleptic characteristics, homogeneity, pH and spreadability, were suitable for topical application. Conclusion: Ag-based gels show antimicrobial action proportional to concentration, with higher action against Gram-negative bacteria and physicochemical stability for oral and skin infection applications.
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