Related Experiment Video
Updated: Jul 15, 2025
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
What to expect after birth in idiopathic polyhydramnios? An analysis of postnatal diagnoses and their relationship to
Sümeyra Gürel1, Işıl Ayhan2, Lütfiye Uygur3
1Obstetrics and Gynecology, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, Istanbul, Turkey.
Insights
Idiopathic polyhydramnios, especially moderate to severe cases, is linked to postnatal abnormalities. These include neurodevelopmental, genetic, and gastrointestinal issues, highlighting the need for careful monitoring.
Area of Science:
- Perinatology
- Neonatal Abnormalities
- Pregnancy Complications
Background:
- Idiopathic polyhydramnios, a condition of excess amniotic fluid without a clear cause, affects fetal development.
- Understanding associated postnatal risks is crucial for timely intervention and improved outcomes.
Purpose of the Study:
- To investigate postnatal abnormalities in idiopathic polyhydramnios.
- To determine the association between the severity of polyhydramnios and diagnosed abnormalities after birth.
Main Methods:
- Retrospective cohort study of 242 pregnancies with idiopathic polyhydramnios (2017-2021).
- Exclusion criteria included known fetal anomalies, genetic disorders, and maternal conditions.
- Analysis focused on the correlation between polyhydramnios degree and postnatal diagnoses.
Main Results:
- 16.1% of infants born to mothers with idiopathic polyhydramnios had at least one abnormality.
- Moderate and severe polyhydramnios showed a significant association with postnatal abnormalities (45.9% and 41.6%, respectively).
- Neurodevelopmental disorders, genetic abnormalities, and gastrointestinal issues were the most frequent findings.
Conclusions:
- Moderate and severe idiopathic polyhydramnios are significantly linked to postnatal anomalies.
- Increased risks for neurodevelopmental disorders, genetic abnormalities, and gastrointestinal atresias are observed.
Purpose:
To analyze postnatal abnormalities in idiopathic polyhydramnios and to estimate whether there was an association between the severity of polyhydramnios and postnatally diagnosed abnormalities.
Methods:
This was a retrospective cohort study of all idiopathic polyhydramnios cases delivered at our center between 2017 and 2021. Cases were identified as idiopathic after excluding known fetal genetic or structural abnormalities (including soft markers for aneuploidies), Rh isoimmunization, fetal anemia, multifetal pregnancies, pregestational or gestational diabetes, and known infection with TORCH group agents. The primary outcome was the association between polyhydramnios degree and any abnormalities detected after birth. Additional outcomes were the odds of specific groups of abnormalities based on polyhydramnios degree.
Results:
The prevalence of idiopathic polyhydramnios was 14.7%. Outcomes of 242 pregnancies with idiopathic polyhydramnios were analyzed. At least one neurodevelopmental, structural, or genetic abnormality was diagnosed in 16.1% of children born to women with idiopathic polyhydramnios. Moderate and severe polyhydramnios are significantly associated with at least one abnormality diagnosed after birth (45.9%, and 41.6%, respectively, p < 0.05). Neurodevelopmental disorders were the most frequent abnormality (5.4%), followed by genetic abnormalities (4.1%) and gastrointestinal abnormalities (2%). Odds of genetic abnormalities and neurodevelopmental disorders in moderate polyhydramnios were significantly higher compared to mild [OR 2.6; 95% CI 1.1-4.3 and aOR 2.4 (95% CI 1.1-3.6) respectively]. As expected, gastrointestinal anomalies were significantly associated with severe polyhydramnios [OR 3.2 (95% CI 1.9-5.5)].
Conclusion:
Moderate and severe idiopathic polyhydramnios are associated with anomalies diagnosed after birth. Particularly high risks include neurodevelopmental disorders, genetic abnormalities, and gastrointestinal atresias.
Related Concept Videos
01:20Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
01:19Mitral Valve Prolapse III: Nursing Management
01:07Teratogenicity