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Consanguinity as a Risk Factor for Autism.

Fouad A Alshaban1, Mohammad Aldosari2, Iman Ghazal1

  • 1Qatar Biomedical Research Institute, Neurological Disorders Research Center, Hamad Bin Khalifa University, Education City, Qatar Foundation, Doha, Qatar.

Journal of Autism and Developmental Disorders
|September 26, 2023
PubMed
Summary
This summary is machine-generated.

Parental consanguinity was not found to be a risk factor for Autism Spectrum Disorders (ASD) in a Qatari study. This finding suggests that while consanguinity is common in some regions, it may not increase autism risk.

Keywords:
ASDAutismConsanguinityParental ageRisk factorSex

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Area of Science:

  • Genetics and environmental factors in neurodevelopmental disorders.
  • Epidemiology of Autism Spectrum Disorders (ASD).

Background:

  • Autism Spectrum Disorders (ASD) research investigates genetic and environmental risk factors globally.
  • Consanguinity, or marriage within families, is prevalent in the Middle East, North Africa, and Asia.
  • Previous studies on consanguinity as an ASD risk factor have yielded inconsistent results.

Purpose of the Study:

  • To evaluate the association between parental consanguinity and the risk of Autism Spectrum Disorders (ASD).
  • To utilize registry and survey data from Qatar for this investigation.

Main Methods:

  • A sample of 891 children (361 with ASD, 530 without) was selected from a national autism registry and survey in Qatar.
  • Data on consanguinity and other relevant factors were gathered through questionnaires and interviews.
  • Statistical analyses, including adjusted multiple logistic regression, were performed.

Main Results:

  • The prevalence of consanguinity in the study sample was 41.2%, with no significant difference between children with ASD and controls.
  • Adjusted logistic regression analyses indicated no statistically significant association between consanguinity and the risk of ASD (aOR = 1.065; 95% CI: .751-1.509).

Conclusions:

  • Parental consanguinity did not demonstrate an association with an increased risk of Autism Spectrum Disorders in this Qatari population.
  • Further research replicating these findings in other populations with high rates of consanguineous unions is recommended.