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Christopher A Butts1, Saskya Byerly, Jeffry Nahmias

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The Journal of Trauma and Acute Care Surgery
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PubMed
Summary
This summary is machine-generated.

Researchers developed a core outcome set (COS) for appendicitis studies. This standardization aims to improve consistency and data pooling in future research on appendicitis management.

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Area of Science:

  • Surgery
  • Clinical Research
  • Evidence-Based Medicine

Background:

  • Appendicitis is a common surgical pathology with inconsistent literature regarding outcomes, particularly for nonoperative management.
  • Existing studies exhibit outcome heterogeneity, hindering data pooling and comparative analysis.
  • A standardized approach is needed to improve the quality and comparability of appendicitis research.

Purpose of the Study:

  • To develop a Core Outcome Set (COS) for appendicitis research.
  • To standardize outcome measurement in appendicitis studies.
  • To facilitate future data pooling and meta-analyses.

Main Methods:

  • A modified Delphi study involving 16 international appendicitis experts.
  • Three rounds of outcome suggestion and scoring using a 1-9 Likert scale.
  • Consensus defined as >70% of scores 7-9 and <15% of scores 1-3.

Main Results:

  • Seventeen potential outcomes were initially identified.
  • A total of 17 outcomes achieved consensus for the COS.
  • The consensus rate for the final COS was 53% of the initially suggested outcomes.

Conclusions:

  • An international expert panel reached consensus on 17 core outcomes for appendicitis studies.
  • This COS provides a minimum set of standardized outcomes for future research.
  • The established COS will aid in framing future cohort studies and improving data comparability.