Evidence-Based Management of Chronic Lymphocytic Leukemia: Consensus Statements from the Gulf Region

Area of Science:

• Hematology
• Oncology

Background:

• Chronic lymphocytic leukemia (CLL) remains largely incurable despite advances.
• Lack of regional consensus guidelines leads to variable patient management practices.

Purpose of the Study:

• To establish expert consensus on CLL definitions, classifications, and management practices.
• To provide guidance for healthcare professionals managing CLL patients.
• To serve as a foundation for developing regional CLL guidelines.

Main Methods:

• Modified Delphi consensus methodology employed.
• Eight hematology experts responded to 50 statements.
• Consensus reached with >=75% agreement.

Main Results:

• Consensus achieved on nearly all 50 statements covering CLL diagnosis, staging, risk assessment, treatment, and complications.
• Discussions included prognostic evaluation, therapy sequences, and management during the COVID-19 pandemic.

Conclusions:

• The consensus synthesizes decades of principles, new research, and future prospects in CLL management.
• It aims to standardize and improve the care of CLL patients through expert-driven recommendations.