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Thyroid disorders and male sexual dysfunction
Rohan Morenas1, Danish Singh1, Wayne J G Hellstrom2
1Department of Urology, Section of Andrology, Tulane University School of Medicine, New Orleans, LA, USA.
International Journal of Impotence Research
|September 26, 2023
Summary
Thyroid disorders significantly impact male sexual dysfunction (SD), affecting erectile function, spermatogenesis, and the hypothalamic-pituitary-gonadal axis. Recognizing this link is crucial for diagnosing and managing male sexual health.
Area of Science:
- Endocrinology
- Urology
- Reproductive Medicine
Background:
- Early research overlooked thyroid hormone involvement in male reproductive functions.
- Recent decades show increasing evidence linking thyroid disorders to male sexual dysfunction (SD).
Purpose of the Study:
- To review literature on thyroid disorders and male SD from 1963-2022.
- To define diagnostic considerations, pathophysiology, and management strategies for SD secondary to thyroid dysregulation.
Main Methods:
- Conducted a comprehensive literature review of clinical and preclinical studies.
- Focused on studies published between 1963 and 2022.
Main Results:
- Thyroid dysregulation is linked to erectile dysfunction, ejaculatory dysfunction, and impaired spermatogenesis.
- Disruption of the hypothalamic-pituitary-gonadal axis is a key pathophysiological mechanism.
- Thyroid disorders are a significant contributing factor to male SD.
Conclusions:
- Thyroid disorders are integral to the pathophysiology of male sexual dysfunction.
- This review provides a framework for clinicians evaluating patients with concurrent thyroid and SD issues.
- Further research is needed to fully elucidate the underlying mechanisms.
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