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Two new quinolinone glycoalkaloids from Chrysanthemum indicum L. and their antimicrobial activity
Qingsong Zhu1, Songhu Liu1, Min Zhai1
1Xinyang Agricultural and Forestry University, Xinyang, Henan Province, China.
Abstract:
Phytochemical investigation of Chrysanthemum indicum L. yielded two new quinolinone glycoalkaloids named as Chrysanthemumsides A-B (1-2). The structures of the new compounds were elucidated by analysis of their 1D- and 2D-NMR, HRESIMS and ECD calculations. Compounds 1-4 were evaluated for antimicrobial activity against the Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans, and the data showed that compound 2 had significant antimicrobial effects (MIC 3.9 to 7.8 μg/mL).
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