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Updated: Jul 15, 2025

The Influence of Liver Resection on Intrahepatic Tumor Growth
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The Influence of Liver Resection on Intrahepatic Tumor Growth

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Regulatory mechanism underlying liver X receptor effects on the tumor microenvironment, inflammation and

Heng Zhang1, Jing Wang2, Jiang Sun3

  • 1Department of General Surgery, Nanjing Lishui District People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, China.

Expert Opinion on Therapeutic Targets
|September 27, 2023
PubMed
Abstract

Insights

Liver X receptors (LXRs) are promising targets for cancer therapy. These receptors influence tumor growth by modulating immune cells and inflammation within the tumor microenvironment, offering new therapeutic strategies.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Liver X receptors (LXRs) are increasingly recognized for their role in cancer.
  • LXRs influence the tumor microenvironment by regulating immune cell infiltration and cytokine release.
  • Abnormal LXR expression is observed in various tumor tissues.

Purpose of the Study:

  • To systematically review the impact of LXRs on the tumor microenvironment and tumorigenesis.
  • To summarize the antitumor effects of LXRs, particularly their regulation of cytokine expression.
  • To highlight the multifaceted role of LXRs in cancer, considering their effects on immune cells.

Main Methods:

  • Systematic review of recent scientific literature.
  • Analysis of studies investigating LXR expression and function in tumors.
  • Synthesis of findings on LXR-mediated regulation of immune cells and cytokines.

Main Results:

  • LXR activation can inhibit tumorigenesis and promote apoptosis in tumor cells.
  • LXRs modulate immune cell functions within the tumor immune microenvironment.
  • LXR regulation of cytokine expression contributes to antitumor effects.

Conclusions:

  • LXRs represent multifaceted targets for cancer treatment.
  • Understanding LXR's interaction with the immune microenvironment is crucial for developing novel therapies.
  • Further research is needed to address limitations in current LXR tumor studies.
Keywords:
Liver X receptorcancercytokineimmune cellinflammationtumor microenvironment

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