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Updated: Jul 15, 2025

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Published on: December 21, 2019
Prediction of mammalian virus cross-species transmission based on host proteins
Zheng Zhang1,2, Congyu Lu1, Bocheng Mo2
1Bioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University , Changsha, Hunan, China.
Importance:
Emerging viruses pose serious threats to humans. Understanding the mechanism of virus cross-species transmission and identifying zoonotic viruses before their emergence are critical for the prevention and control of emerging viruses. This study systematically identified host factors associated with cross-species transmission of mammalian viruses and further built machine-learning models for predicting cross-species transmission of the viruses based on host factors including virus receptors. The study not only deepens our understanding of the mechanism of virus cross-species transmission but also provides a framework for predicting the cross-species transmission of mammalian viruses based on host factors.
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