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Contemporary Evaluation and Clinical Treatment Options for Aortic Regurgitation

Mark Lebehn1, Torsten Vahl1,2, Polydoros Kampaktsis1

  • 1Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.

Journal of Cardiovascular Development and Disease
|September 27, 2023
PubMed

Insights

Aortic regurgitation (AR) affects many older adults. Accurate assessment of AR severity and its impact on the left ventricle is crucial for timely intervention and improved outcomes.

Area of Science:

  • Cardiology
  • Valvular Heart Disease
  • Medical Imaging

Background:

  • Aortic regurgitation (AR) is a prevalent valvular heart disease, increasing with age.
  • Understanding aortic valve and root structure is key to AR etiology and mechanisms.
  • Acute and chronic AR have distinct hemodynamic impacts and management strategies.

Purpose of the Study:

  • To review the importance of aortic regurgitation (AR) in an aging population.
  • To discuss the differing hemodynamic impacts and management of acute versus chronic AR.
  • To highlight the need for multiparametric imaging in assessing AR severity and left ventricular function.

Main Methods:

  • Review of current literature on aortic regurgitation (AR) pathophysiology and management.
  • Analysis of diagnostic imaging modalities including echocardiography, CT, and CMR.
  • Evaluation of emerging transcatheter therapies and assessment methods for AR.

Main Results:

  • Current guidelines may lead to delayed intervention for chronic AR, impacting outcomes.
  • Multiparametric imaging is essential for accurate quantitation of ventricular function and AR severity.
  • Echocardiography is primary, supplemented by CT and CMR.

Conclusions:

  • Accurate assessment of AR severity and LV function is critical for optimal patient outcomes.
  • Novel imaging and therapeutic approaches are needed to improve management, especially for high-risk patients.
  • Timely intervention, guided by comprehensive imaging, is key in managing aortic regurgitation.

Keywords:
aortic regurgitationechocardiographytranscatheter aortic valve replacement

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