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Noninvasive Prediction of Sperm Retrieval Using Diffusion Tensor Imaging in Patients with Nonobstructive Azoospermia.
Sikang Gao1, Jun Yang2, Dong Chen3
1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Journal of Imaging
|September 27, 2023
Summary
Diffusion tensor imaging (DTI) can predict sperm retrieval success in nonobstructive azoospermia (NOA). Mean diffusivity values from DTI show promise as a noninvasive marker to identify patients likely to succeed with microdissection testicular sperm extraction (mTESE).
Area of Science:
- Urology
- Radiology
- Reproductive Medicine
Background:
- Microdissection testicular sperm extraction (mTESE) is standard for nonobstructive azoospermia (NOA).
- Sperm retrieval rates (SRR) range from 43-63%, with many patients experiencing retrieval failure.
Purpose of the Study:
- To assess diffusion tensor imaging (DTI) parameters for predicting SRR in NOA patients undergoing mTESE.
- To identify noninvasive imaging markers for successful sperm retrieval.
Main Methods:
- Seventy NOA patients were divided into successful (29) and failed (41) mTESE groups.
- Scrotal MRI was performed, analyzing DTI parameters like mean diffusivity (MD) and fractional anisotropy (FA).
Main Results:
- Mean diffusivity showed a significant difference between success and failure groups (AUC=0.865, sensitivity=72.2%, specificity=97.5%).
- Fractional anisotropy and sex hormone levels did not differ significantly between groups.
Conclusions:
- Mean diffusivity derived from DTI is a potential noninvasive imaging biomarker for predicting mTESE success in NOA patients.
- DTI offers a promising tool to guide treatment decisions and manage patient expectations.
