Related Experiment Video
Updated: Jul 12, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
On the comparability of frailty scores under the accumulation of deficits approach
Curtis Huffman1, Héctor Nájera1, Mario Ulises Pérez Zepeda2
1Programa Universitario de Estudios del Desarrollo, Coordinación de Humandiades, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City, Mexico.
Background:
While the cumulative deficit model is arguably the most popular instrument for population-level frailty screening, several questions remain unanswered regarding the comparability of the resulting scores across subpopulations.
Methods:
Based on data from the five waves of the Mexican Health and Aging Study (MHAS) we draw upon the alignment method to test for measurement invariance of frailty scores as per the accumulation of deficits approach.
Results:
Our results show that adjusting for measurement non-invariance not only improves predictive validity of our frailty measures, but resulting scores are more consistent with what is theoretically expected from them in longitudinal research.
Conclusions:
There are clear potential benefits of measurement invariance testing as a general analytical framework from which to tackle with issues of comparability in frailty research.

