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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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cfOmics: a cell-free multi-Omics database for diseases.

Mingyang Li1,2,3,4, Tianxiu Zhou1,2, Mingfei Han5

  • 1MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Nucleic Acids Research
|September 27, 2023
PubMed
Summary
This summary is machine-generated.

The cfOmics database offers integrated multi-omics liquid biopsy data to identify disease biomarkers. This resource aids researchers in analyzing cell-free DNA, RNA, proteome, and metabolome for improved diagnostics and treatment monitoring.

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Area of Science:

  • Biomarker Discovery
  • Genomics
  • Proteomics
  • Metabolomics
  • Liquid Biopsy

Background:

  • Liquid biopsy is a non-invasive method for disease detection, monitoring, and recurrence prediction.
  • Challenges remain in effectively utilizing liquid biopsy data for reliable biomarker identification across diseases.
  • A comprehensive, integrated resource for multi-omics liquid biopsy data is needed.

Purpose of the Study:

  • To introduce cfOmics, the first web-accessible database integrating multi-omics liquid biopsy data.
  • To provide a centralized resource for researchers to explore cell-free data.
  • To facilitate the discovery of novel biomarkers for disease diagnosis and management.

Main Methods:

  • Integration of diverse liquid biopsy data types: cell-free DNA (cfDNA), cell-free RNA (cfRNA) via next-generation sequencing, and proteome/metabolome via mass spectrometry.
  • Database construction encompassing 17 data types, 13 specimen variations, 69 disease conditions, and 11,345 samples.
  • Development of analytical and visualization tools including browsing, profile visualization, Integrative Genomic Viewer, and correlation analysis.

Main Results:

  • cfOmics is established as a comprehensive, web-accessible database (https://cfomics.ncRNAlab.org/).
  • The database integrates multi-omics data from liquid biopsies, covering a wide range of diseases and sample types.
  • Includes a curated list of potential biomarkers for user reference.

Conclusions:

  • cfOmics provides a valuable resource for researchers in the liquid biopsy field.
  • The integrated multi-omics data and analytical tools can accelerate biomarker discovery.
  • This resource has the potential to significantly impact disease diagnosis, treatment monitoring, and patient management.