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Re-evaluating the mosquito RNAi pathway's influence on arbovirus transmission
1The Pirbright Institute, Ash Road, Pirbright, Surrey GU24 0NF, UK.
Trends in Parasitology
|September 27, 2023
Abstract
None:
With new RNA interference (RNAi) pathway-deficient mosquitoes, Merkling et al. invite a shift in our view of this pathway's role in regulating arthropod-borne virus (arbovirus) transmission. While loss of RNAi function enhanced early viral replication, little impact on transmission was observed, inviting renewed exploration of molecular barriers to arbovirus transmission.
