[Effectiveness of essentiale and vitohepatum as stabilizers of liver lysosomal membranes]

Essentiale or vitohepatum were administered into 26-28 months old Wistar rats to stabilize the lysosomal membranes. Administration of essentiale (cyancobalamine standardization at a dose of 0.286 microgram/kg) within 21 days led to a decrease in total activity of acid DNAase, acid phosphatase, cathepsin D, hyaluronidase without distinct changes in acid RNAase activity. Vitohepatum administered similarly (cyancobalamine standardization at a dose of 0.27 microgram/kg) caused a decrease in total activity of lysosomal enzymes acid DNAase acid phosphatase, cathepsin D, did not affect hyaluronidase and acid RNAase activities. The administration of the both drugs was also accompanied by a decrease in non-sedimented activity of the enzymes studied.