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Updated: Jul 15, 2025

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
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Modulation of Skin Cancer by the Stimulator of Interferon Genes

Max Oscherwitz1, Victoria Jiminez1, Hanna Terhaar1

  • 1Heersink School of Medicine, University of Alabama, Birmingham, AL 35294, USA.

Genes
|September 28, 2023
PubMed

Insights

The stimulator of interferon genes (STING) pathway plays a role in skin cancer development. STING-based therapies show promise for treating melanoma and non-melanoma skin cancers, with potential for synergistic effects in future treatments.

Area of Science:

  • Dermatology and Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Rising global incidence of melanoma and non-melanoma skin cancers (NMSC).
  • Increasing interest in the stimulator of interferon genes (STING) pathway in skin cancer pathogenesis.
  • Need for novel therapeutic strategies beyond current treatments.

Purpose of the Study:

  • To review the STING pathway's role in DNA damage and skin cancer.
  • To summarize current and potential STING-specific therapies for NMSC and melanoma.
  • To explore synergistic applications and limitations of STING-based treatments.

Main Methods:

  • Literature review of STING pathway mechanisms.
  • Analysis of STING's involvement in skin carcinogenesis.
  • Evaluation of existing and emerging STING-targeted therapies.

Main Results:

  • The STING pathway is implicated in the pathogenesis of skin cancers.
  • STING-specific therapies demonstrate potential against melanoma and NMSC.
  • Specific STING pathway components may enhance existing treatments.

Conclusions:

  • The STING pathway is a critical target for skin cancer therapy.
  • STING-based approaches offer a promising avenue for novel oncology treatments.
  • Further research is needed to overcome limitations of current STING therapies.
Keywords:
BCCSCCSTINGbasal cell carcinomaimmunotherapyinterferonsmelanomaskin cancersquamous cell carcinoma

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