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Generation of Human Cardiomyocytes: A Differentiation Protocol from Feeder-free Human Induced Pluripotent Stem Cells
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Flagellin-Induced Immune Response in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Goekhan Yuecel1,2, Xiaobo Zhou1,2, Linda Terkatz1,3

  • 1Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.

International Journal of Molecular Sciences
|September 28, 2023
PubMed
Summary

Pathogen-associated molecular patterns (PAMPs) trigger septic cardiomyopathy via toll-like receptor (TLR) signaling. This study shows human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) can model PAMP-induced immune responses in heart cells.

Keywords:
PAMPTLRhiPSC-CMinnate immunityseptic cardiomyopathy

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