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Pregnancy by Oocyte Donation: Reviewing Fetal-Maternal Risks and Complications.
Erica Silvestris1, Easter Anna Petracca1, Michele Mongelli2
1Gynecologic Oncology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", 70124 Bari, Italy.
International Journal of Molecular Sciences
|September 28, 2023
Summary
Oocyte donation (OD) offers a successful path to motherhood for infertile women by overcoming ovarian reserve issues. However, it may increase risks of pregnancy complications and maternal-fetal issues.
Area of Science:
- Reproductive Medicine
- Obstetrics
- Immunology
Background:
- Oocyte donation (OD) is a key assisted reproductive technology (ART) for infertility.
- It addresses ovarian reserve exhaustion and age-related gamete quality decline.
- OD has significantly improved pregnancy rates for many women.
Purpose of the Study:
- To review the success of oocyte donation in achieving pregnancy.
- To critically examine the associated risks and complications of OD.
- To provide a balanced perspective on OD procedures.
Main Methods:
- Literature review of studies on oocyte donation outcomes.
- Analysis of pregnancy rates and complication data.
- Synthesis of information on maternal-fetal outcomes and immune interactions.
Main Results:
- Oocyte donation demonstrates high success rates for achieving pregnancy.
- Associated risks include increased rates of miscarriage, infections, and placental diseases.
- Potential maternal-fetal complications arise from gamete manipulation and immune responses.
Conclusions:
- Oocyte donation is a valuable ART but requires careful consideration of risks.
- Further research is needed to mitigate complications associated with OD.
- Balancing successful pregnancy outcomes with maternal and fetal safety is crucial.
