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09:30
The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
Published on: October 7, 2016
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Bioactive Endodontic Hydrogels: From Parameters to Personalized Medicine
Marianne Leveque1, Mourad Bekhouche1, Jean-Christophe Farges1,2,3
1Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique, UMR 5305 CNRS/UCBL, 69007 Lyon, France.
International Journal of Molecular Sciences
|September 28, 2023
Summary
Regenerative endodontic procedures (REPs) use hydrogels to regenerate dental pulp. Understanding hydrogel parameters is key to predicting outcomes and advancing regenerative endodontics from the lab to the clinic.
Area of Science:
- Biomaterials Science
- Endodontics
- Tissue Engineering
Background:
- Regenerative endodontic procedures (REPs) aim to regenerate dental pulp tissue using hydrogel biomaterials.
- The bioactivity of endodontic hydrogels is influenced by biomolecules, but also by parameters like concentration, solubility, and apex size.
- Current understanding of these parameters limits the prediction of clinical outcomes and hinders the translation of regenerative endodontics.
Purpose of the Study:
- To review and identify key parameters influencing endodontic hydrogel bioactivity.
- To discuss challenges and future perspectives for predicting hydrogel behavior in regenerative endodontics.
- To bridge the gap between laboratory findings and clinical applications in regenerative endodontics.
Main Methods:
- Literature review of parameters affecting endodontic hydrogel bioactivity.
- Analysis of factors influencing the host-biomaterial interaction in REPs.
- Exploration of challenges and future directions for mathematical modeling in regenerative endodontics.
Main Results:
- Identified multiple parameters beyond biomolecule composition that significantly impact hydrogel behavior and host interaction.
- Highlighted the lack of comprehensive understanding of these parameters as a barrier to predictable clinical outcomes.
- Emphasized the potential for mathematical models to explain and predict endodontic hydrogel bioactivity.
Conclusions:
- Most parameters influencing endodontic hydrogel bioactivity can be identified, described, and studied.
- Addressing these parameters is crucial for the successful clinical translation of regenerative endodontic procedures.
- Future development of predictive mathematical models is essential for advancing regenerative endodontics.
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