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The Possible Role of NLRP3 Inflammasome in Depression and Myocardial Infarction Comorbidity

Erensu Baysak1, Cagan Yildirim2, Nurten Sayar2

  • 1Department of Psychiatry, School of Medicine, Marmara University, Istanbul 34854, Turkey.

Journal of Personalized Medicine
|September 28, 2023
PubMed

Insights

The NOD-like receptor protein 3 (NLRP3) inflammasome pathway may contribute to depression in myocardial infarction patients. Higher NLRP3 levels were linked to an increased likelihood of depression, warranting further investigation.

Area of Science:

  • Cardiovascular Medicine
  • Psychiatry
  • Immunology

Background:

  • Cardiovascular disease and depression frequently co-occur.
  • The role of inflammation, specifically the NLRP3 inflammasome pathway and hsCRP, in this comorbidity is not fully understood.

Purpose of the Study:

  • To investigate the association between the NLRP3 inflammasome pathway, hsCRP, and depression in patients with incident myocardial infarction.
  • To determine if NLRP3 inflammasome pathway activation is linked to depression in myocardial infarction patients.

Main Methods:

  • Sixty-eight patients with ST-elevation myocardial infarction and twenty healthy controls were enrolled.
  • Patients were assessed for depression using the Structured Clinical Interview for DSM-5 Disorders-Clinician Version.
  • Levels of NLRP3, IL-18, IL-1β, and hsCRP were measured using ELISA.

Main Results:

  • Myocardial infarction patients exhibited significantly higher levels of NLRP3, IL-1β, IL-18, and hsCRP compared to healthy controls.
  • No significant differences in these markers were observed between myocardial infarction patients with and without depression.
  • Logistic regression revealed that NLRP3 levels significantly predicted the likelihood of depression in myocardial infarction patients (OR = 1.72, CI = 1.11-2.66).

Conclusions:

  • While direct differences in NLRP3 pathway markers were not found between depressed and non-depressed myocardial infarction patients, NLRP3 activation is associated with an increased likelihood of depression.
  • The NLRP3 inflammasome pathway may play a role in the development of depression in the context of myocardial infarction.
  • Further research with larger sample sizes is recommended to confirm these findings.

Keywords:
NLRP3NOD-like receptor protein 3depressionhsCRPmyocardial infarction

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