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Causal Link between Gut Microbiota, Neurophysiological States, and Bone Diseases: A Comprehensive Mendelian
Shaoting Luo1, Zhiyang Chen2, Linfang Deng3
1Department of Pediatric Orthopedics, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Nutrients
|September 28, 2023
Summary
This study reveals a causal link between gut bacteria and bone health, suggesting that optimizing gut microbiota may prevent knee osteoarthritis and fractures by improving cognition and sleep.
Area of Science:
- Microbiome research
- Skeletal biology
- Genetics
Background:
- Growing evidence links gut microbiota to bone diseases.
- The causal relationship between gut microbiota and skeletal health remains largely undetermined.
Purpose of the Study:
- To investigate the causal relationship between gut microbiota and skeletal diseases.
- To explore the mediating role of neuropsychological states in this relationship.
Main Methods:
- Genome-wide association studies (GWAS)
- Linkage disequilibrium score regression (LDSC)
- Mendelian randomization (MR)
- Mediation analysis
- Genetic colocalization analysis
Main Results:
- Identified a causal link between Ruminococcaceae and knee osteoarthritis (OA), mediated by cognitive performance and insomnia.
- Found a causal association between Burkholderiales and lumbar pelvic fractures, mediated by cognitive performance.
- Discovered a shared causal variant (rs2352974) for cognitive ability and knee OA.
Conclusions:
- Gut microbiota alterations can positively influence cognitive function and insomnia.
- Optimizing gut microbiota may offer novel strategies for preventing fractures and osteoarthritis.
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