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Development of Simvastatin-Loaded Particles Using Spray Drying Method for Ex Tempore Preparation of Cartridges for 2D
Barbara Sterle Zorec1, Rok Dreu1
1Faculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, SI-1000 Ljubljana, Slovenia.
Pharmaceutics
|September 28, 2023
Summary
Spray drying created simvastatin/polycaprolactone microparticles for 2D printing inks. Nanocellulose/lactose particles offered optimal size and stability, enhanced by ascorbic acid.
Area of Science:
- Pharmaceutical Technology
- Materials Science
- Chemical Engineering
Background:
- Developing novel drug delivery systems for personalized medicine.
- Exploring microparticle formulations for 3D/2D printing applications.
- Investigating the stability and printability of drug-loaded microparticles.
Purpose of the Study:
- To develop spray-dried simvastatin/polycaprolactone microparticles for 2D printing.
- To evaluate particle characteristics, encapsulation efficiency, and stability.
- To assess the suitability of different particle formulations for printable ink media.
Main Methods:
- Spray drying of simvastatin/polycaprolactone with various excipients (lactose, nanocellulose/lactose, calcium silicate).
- Characterization of particle size, simvastatin encapsulation efficiency, and chemical stability.
- Dispersion studies in propylene glycol/water mixtures to assess printability.
Main Results:
- Nanocellulose/lactose particles exhibited highest simvastatin encapsulation efficiency.
- Ascorbic acid improved drug stability, while antioxidants negatively impacted calcium silicate particles.
- Nanocellulose/lactose dispersions maintained particle size (<1 µm) and stability in printable ink media.
Conclusions:
- Spray-dried simvastatin/polycaprolactone microparticles are promising for 2D printing.
- Nanocellulose/lactose formulation demonstrates superior properties for printable drug delivery.
- Further research can optimize antioxidant use for enhanced drug stability in printed formulations.
